Wayne C. Guida is Professor in the Department of Chemistry, University of South Florida in Tampa and Professor in the Drug Discovery Program at the H. Lee Moffitt Cancer Center & Research Institute at the University of South Florida. He previously served as President and CEO of Schrödinger, Inc. and continues to serve on the company’s Board of Directors. Prior to his role as CEO of Schrödinger, he was Executive Director of Biomolecular Structure, Lead Finding, and Computing at the Novartis Institute for Biomedical Research (formerly CIBA-Geigy Pharmaceuticals), where he supervised a group of scientists engaged in molecular modeling, structural bioinformatics, X-ray crystallography, protein NMR spectroscopy, protein biochemistry, and high-throughput screening. His work at CIBA-Geigy, along with collaborators at several other institutions, resulted in one of the first successful examples of the use of structure-based drug design in drug discovery. That work led to the development of clinically tested inhibitors of purine nucleoside phosphorylase. Prior to joining CIBA-Geigy, Dr. Guida was one of the original developers of the MacroModel program at Columbia University.