Matthew P. Jacobson is an Associate Professor and Vice Chair in the Department of Pharmaceutical Chemistry at UCSF. He is the recipient of an NSF Career award and an Alfred P. Sloan Fellowship. Research interests in the area of computer-aided drug design include docking against homology models and flexible protein binding sites, membrane permeability, and antibody modeling. Other research interests include mechanisms of protein regulation by post-translational modifications, allostery, and pH.