Is it possible to use multiple templates to build a homology model?

Yes. Prime is capable of using multiple templates to build a composite model. See the 'Comparative Modeling: Build Structure' section of the Prime User Manual. Using 'Set template regions', you can identify the regions from each template to use in the model.

From Suite 2011 on, you can use multiple templates to build a consensus model as well, and you can also build a multimer model.

Keywords: Prime, multiple templates, homology model

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