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Article ID: 1366 - Last Modified:

How do I build a multimeric homology model with Prime using a multi-chain template?

You can build multimers from the Prime Structure Prediction panel. For a homomultimer, you can select multiple templates and align them, then in the build step you can build a multimer. For a heteromultimer, you create a separate run for each chain, taking each run to the beginning of the Build Structure step, and then you select all the runs to build the structure.

If you want to build a multimer from the command line, you can set up a job for each chain in Maestro, and write the input files rather than run the job. Then run bldstruct from the command line, listing all the input files as arguments:

$SCHRODINGER/bldstruct chain1.inp chain2.inp ...

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