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Article ID: 155 - Last Modified:

I have a class B or C GPCR sequence, can I use the "align GPCR" mode to align my sequence to the template?

The short answer is No. The "Align GPCR" mode is designed to align class A sequences with class A templates using known conserved sequence motifs. These motifs do not exist in the class B or C families. The best approach here is to follow the standard homology modeling procedure in Prime.

Keywords: GPCR, Prime, Alignment, Homology Model

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