Is there a way to manually adjust in real time the conformation of a small molecule or protein in Maestro?

There is a "sculpting" tool available from the Build toolbar that allows you to adjust the conformation of anything in the Maestro workspace by clicking on an atom and dragging it to a new location. When you let go of the mouse, the molecule will be quickly minimized in real-time. You can use the sculpting tool to do things like stretch out a molecule to an extended conformation, easily adjust the conformation of a cyclohexyl ring (e.g., boat to chair), form an H-bond in a protein, etc.

View this tutorial video in 720p HD full screen to see how to use the Sculpting tool in Maestro:

If you are having trouble viewing the above video, you may download it by clicking here.

Keywords: Maestro, sculpting, Build toolbar, fast minimization

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