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Article ID: 1648 - Last Modified:

Can I use Glide to score poses produced by Prime Covalent Docking?

We recommend the new Covalent Docking protocol, introduced in the 2013-1 release, which uses both Glide and Prime, and provides a scoring algorithm that is more suited to covalently bound ligands. Conventional Glide scoring is not really appropriate for covalently bound ligands, as it is intended to provide an estimate of noncovalent binding free energy.

Keywords: rank ordering

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