How long does it take to screen a Phase database?

Screening time is dependent on a number of factors: the speed of the disk, the number of processors, and most importantly, the nature of the query. A highly selective hypothesis that matches only a small fraction of compounds will result in a much faster search. A screen that matches only about 5% of the database proceeds at a speed of about 25 compounds per second per processor. That takes into account the fact that most compounds are eliminated in the key-based pre-screen, so each processor is not actually searching 25 compounds per second. Rather, 25 compounds/sec is the formal speed based on the number of compounds formally assigned to each of the subjobs. A search could take much longer if the hypothesis is very generic, or if partial matching is used.

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