On the output of the following commands:

glxinfo | grep -i opengl -m 3 and
glxinfo | grep -i direct

I got this:

NVIDIA: could not open the device file /dev/nvidiactl (Permission denied).
NVIDIA: Direct rendering failed; attempting indirect rendering.

What does it indicate?

It indicates that the permissions are not set correctly for the device file. The NVidia device permissions should be open to all users. Please check the following:

ls -al /dev/nvidiactl

The result should be either (if root):

crw-rw-rw- 1 root root 195, 255 May 12 16:52 /dev/nvidiactl

or (if user):

crw------- 1 user root 195, 255 May 12 16:52 /dev/nvidiactl

If the permissions are too restrictive, you can change them (as root):

chmod 666 /dev/nvidiactl

You could also try to launch Maestro in software OpenGL mode with the following option:

$SCHRODINGER/maestro -SGL

Keywords: command output, NVIDIA: Direct rendering failed, /dev/nvidiactl, glxinfo, Maestro

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