Would it be better to perform blind docking before proceeding with grid docking?

Glide cannot do blind docking. Its docking algorithm focuses on a specific region of the receptor. However, if you want to explore a large receptor for unknown binding sites, we recommend running SiteMap to identify possible binding locations, and then create grids for these locations for docking. With the cross-docking script (xglide.py) on our website (Resources & Downloads → Script Center), you can run a workflow of docking to multiple grids centered at the sites identified by SiteMap.

Keywords: blind docking, search volume, Glide docking, binding sites

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