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What's the best way of adding a disulfide bond between two cysteine residues in a protein structure?

You can add a bond between two cysteines with the Draw tool on the Build toolbar.

  1. If the Build toolbar is not displayed, display it by clicking the Build button on the Manager toolbar.
  2. Click the Draw button (pencil icon).
  3. Click on the the first sulfur atom, then the second sulfur atom,
    then the second sulfur again (to exit Draw mode).

The bond is drawn between the two sulfurs. By default, any hydrogens are removed from the sulfurs when the bond is drawn. If they are not, you can delete them as follows:

  1. Click and hold on the Delete toolbar button (red X) and choose Atoms.
  2. Click on the hydrogens.

No other changes to the structure are made when you draw the bond.

Keywords: Maestro, connect, disulphide

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