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Article ID: 639 - Last Modified: December 4, 2010

What is considered a good GlideScore?

For Glide SP or HTVS, scores of -10 or lower usually represent good binding. For some targets (e.g., with shallow active sites or predominantly hydrophobic interactions), scores of -8 or -9 might be very good. Metalloproteins and Glide XP both tend to produce lower GlideScores (-12 or below). The cutoff for a "good" score will vary a little from system to system, and changing the van der Waals radii scalings can change the scores significantly.

Keywords: Glide score, docking score, Glide SP, HTVS

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