I found that docking to a subpocket and an entire pocket produced different hits. Why would this happen?

There will be variations in results any time the grid parameters changes. In particular, shifting the grid center will change the results because the site point grid will be different. Generally, these variations are more pronounced for poor binders, where there isn't a strong basin of attraction.

Keywords: Glide, subpocket, pocket, hits, variations, results

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