Article ID: 757 - Last Modified: December 4, 2010
Is there a term in the Glide score that rewards an aromatic C-H/acceptor interaction (where the aromatic C-H is acting as an H-bond donor)?
There is no specific reward and this interaction is not penalized the way other hydrophobic groups would be when blocking a receptor H-bond acceptor. We have not so far found any evidence that an aromatic-H H-bond is worth a reward.
Keywords: aromatic C-H term, Glide
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