Can I use Glide grids from earlier releases with the current software? Or is there some conversion utility to "update" a set of grid files?

You can certainly use grids from earlier releases. Apart from the addition of some new features (and the use of OPLS_2005 from Suite 2010 on instead of OPLS_2001), the basics of grid generation have not changed much. The docking results should be very similar (but likely not identical) to those obtained with newer grids. However, you should not compare docking scores between releases, because the scoring function is being continually developed and reoptimized.

There is no conversion utility to update grid files. If you are concerned about changes in the grid technology, you would have to re-run the grid generation. Fortunately, this is a lot faster now than it was in the past.

Keywords: update grids, Glide

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