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Article ID: 810 - Last Modified: June 7, 2011

While generating pharmacophores using 5 actives, I got the following warning message:

WARNING No hypotheses survived the scoring job. Try relaxing the scoring parameters.

Can you tell me how to change the scoring parameters, or what else I can do?

If no hypotheses survived, you may have to relax the RMSD and vector score criteria. You do this in the Score Actives panel, on the left hand side. You will want to increase the RMSD threshold and decrease the vector score. If that doesn't give anything, you can also try to turn off volume and selectivity score in the Survival Score formula. Sometimes, if the compounds are very different from each other it can be problematic to line up the features or sites.

Keywords: Phase, hypothesis, survive

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