NEW YORK, NY (September 16, 2008) - Schrödinger, Inc. announced today that one of its key publications is the most cited article published in the Journal of Medicinal Chemistry in 2006, as ranked by ACS Publications. The article, titled "Novel Procedure for Modeling Ligand/Receptor Induced Fit Effects1 ," outlines a breakthrough approach to incorporating protein flexibility in ligand-receptor docking based on the Company's Glide and Prime platforms. In addition, another one of Schrödinger's publications from 2006 is the fifth most cited article. The article, titled "Extra Precision Glide: Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein-Ligand Complexes2 ," describes Glide's most accurate level of sampling and scoring methods.
"It is very gratifying that Schrödinger papers are recognized as seminal in the field of molecular modeling. It reaffirms our rigorous approach and our ongoing commitment to making high-impact scientific advances in the field of drug discovery," said Dr. Ramy Farid , Schrödinger's President. "We intend to continue the long tradition at Schrödinger of conducting basic and applied research that we expect will continue to lead to groundbreaking advances in computer-aided drug design."
Furthermore, the original publication for Schrödinger's ligand-receptor docking platform, titled "Glide: A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy3 " ranks seventeenth among the overall most cited Journal of Medicinal Chemistry articles. Published in 2004, the paper is the most recent article on the Journal's top twenty list, with most of the other articles published in 2000 and earlier, another clear indication of this landmark publication's significant impact.
1 Sherman, W.; Day, T.; Jacobson, M. P.; Friesner, R. A.; Farid, R., "Novel Procedure for Modeling Ligand/Receptor Induced Fit Effects," J. Med. Chem., 2006, 49, 534-553.
http://pubs.acs.org/cgi-bin/abstract.cgi/jmcmar/2005/49/i02/abs/jm050540c.html
2 Friesner, R. A.; Murphy, R. B.; Repasky, M. P.; Frye, L. L.; Greenwood, J. R.; Halgren,T. A.; Sanschagrin, P. C.; Mainz, D. T., "Extra Precision Glide: Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein-Ligand Complexes," J. Med. Chem., 2006, 49, 6177-6196.
http://pubs.acs.org/cgi-bin/abstract.cgi/jmcmar/2006/49/i21/abs/jm051256o.html
3 Friesner, R. A.; Banks, J. L.; Murphy, R. B.; Halgren, T. A.; Klicic, J. J.; Mainz, D. T.; Repasky, M. P.; Knoll, E. H.; Shaw, D. E.; Shelley, M.; Perry, J. K.; Francis, P.; Shenkin, P. S, "Glide: A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy," J. Med. Chem., 2004, 47, 1739-1749.
http://pubs.acs.org/cgi-bin/abstract.cgi/jmcmar/2004/47/i07/abs/jm0306430.html
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Contact:
Shi-Yi Liu
(503) 299-1150
Shi-Yi.Liu@schrodinger.com