A full featured key ring
The core features of BioLuminate have been implemented based on extensive market research. Two commonly expressed complaints were: (1) No single package comes close to meeting all the needs in the biologics space; and (2) much of the existing software is difficult or cumbersome to use. This lead to our concept of the key ring — one program to address the most frequently requested functionality for biologics design. BioLuminate is the most complete offering in this space, with key features that include:
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Protein-protein docking
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Antibody structure prediction, including both look-up and advanced loop modeling
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Residue scanning for affinity, stability, and other properties (mutation analysis)
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Cysteine scanning to add and remove disulfides
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Fast homology modeling
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Advanced homology modeling
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Binding site detection and druggability assessment
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Automated identification of reactive hot spots (oxidation, deamidation, etc.)
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Advanced sequence viewer with full annotation and alignment facilities
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Loop and residue mutation tools
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Consensus viewer tool to rapidly identify common structural elements in related proteins
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Low normal mode analysis
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Advanced molecular mechanics conformational sampling
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Alpha-helix stability assessment based on molecular dynamics
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Full access to Schrödinger’s ligand-based tools and other Schrödinger programs
Clearly defined workflows for new functionality
Much of the existing biologics software has been developed in academic labs, where the focus tends to be more on function than on user experience. This leads to software with a steep learning curve that can be confusing or difficult to run, even for experts. This can result in frustration, lost effort, and an increased chance of mistakes. We have designed the new panels in BioLuminate to minimize these issues, with all panels exposing a clear workflow and only the necessary options exposed by default to the user.