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· publication by Schrödinger author
(S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl) propionic Acid, a Potent and Selective Agonist at the GluR5 Subtype of Ionotropic Glutamate Receptors. Synthesis, Modeling, and Molecular Pharmacology
Brehm, L.; Greenwood, J. R.; Hansen, K. B.; Nielsen, B.; Egebjerg, J.; Stensbol, T. B.; Brauner-Osborne, H.; Slok, F. A.; Kronborg, T. T. A.; Krogsgaard-Larsen, P.
J. Med. Chem., 2003, 46, 1350–1358View
Small Molecule Drug Discovery
Synthesis of Novel Thrombin Inhibitors. Use of Ring-Closing Metathesis Reactions for Synthesis of P2 Cyclopentene- and Cyclohexenedicarboxylic Acid Derivatives
Thorstensson, F.; Kvarnstrom, I.; Musil, D.; Nilsson, I.; Samuelsson, B.
J. Med. Chem., 2003, 46, 1165–1179View
Small Molecule Drug Discovery
Rational Design, Synthesis, and Pharmacological Evaluation of 2-Azanorbornane-3-exo,5-endo-dicarboxylic Acid: A Novel Conformationally Restricted Glutamic Acid Analogue
Bunch, L.; Liljefors, T.; Greenwood, J. R.; Frydenvang, K.; Brauner-Osborne, H.; Krogsgaard-Larsen, P.; Madsen, U.
J. Org. Chem., 2003, 68, 1489–1495View
Small Molecule Drug Discovery
Stereostructure-Activity Studies on Agonists at the AMPA and Kainate Subtypes of Ionotropic Glutamate Receptors
Johansen, T. N.; Greenwood, J. R.; Frydenvang, K.; Madsen, U.; Krogsgaard-Larsen, P.
Chirality, 2003, 15, 167–179View
Small Molecule Drug Discovery
Metal-Dependent Inhibition of HIV-1 Integrase
Neamati, N.; Lin, Z.; Karki, R. G.; Orr, A.; Cowansage, K.; Strumberg, D.; Pais, G. C. G.; Voigt, J. H.; Nicklaus, M. C.; Winslow, H. E.; Zhao, H.; Turpin, J. A.; Yi, J.; Skalka, A. M.; Burke, T. R., Jr.; Pommier, Y.
J. Med. Chem., 2002, 45, 5661–5670View
Small Molecule Drug Discovery
Selective Agonists at Group II Metabotropic Glutamate Receptors: Synthesis, Stereochemistry, and Molecular Pharmacology of (S)- and (R)-2-Amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl) butyric Acid
lausen, R. P.; Brauner-Osborne, H.; Greenwood, J. R.; Hermit, M. B.; Stensbol, T. B.; Nielsen, B.; Krogsgaard-Larsen, P.
J. Med. Chem., 2002, 45, 4240–4245View
Small Molecule Drug Discovery
Solvent Models for Protein-Ligand Binding: Comparison of Implicit Solvent Poisson and Surface Generalized Born Models with Explicit Solvent Simulations
Zhang, L.Y.; Gallicchio, E.; Friesner, R.A.; Levy, R.M.
J. Comput. Chem., 2001, 22, 591–607View