The science of vaccine development has made remarkable progress in the last two decades. Originally, vaccine design was centered around the isolate-inactivate-inject paradigm. This process involved extracting pathogens or associated toxins and then inactivating or attenuating them before administration. In recent years, advances in structural biology and other technologies have introduced the era of rational vaccine design in which recombinant protein antigens are modified to achieve desired properties.

During this webinar, we will go over common problems in structure-based vaccine design and show how Schrödinger's biologics modeling suite can be used in the engineering of protein antigens to improve safety, efficacy, and developability.