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Sometimes the results returned from Glide have slightly distorted aromatic rings. Can I prevent this?

Distorted aromatic rings are not necessarily unphysical, because the out-of-plane bending mode frequencies are not infinite. There are some target-ligand combinations where interactions can outweigh the improper torsions in the OPLS force field, so the distorted rings are not a bug. However, nonplanarity can also be a result of rigid-receptor docking.

You can significantly increase the force constant for the out-of-plane bending of aromatic rings (and other groups that should be essentially planar) by selecting "Enhance planarity of conjugated pi groups" in the Settings tab of the Ligand Docking panel, or by adding the following line to the Glide input file (


The increased force constant should prevent rings and other groups from distorting out of the plane. This term does not affect post-docking minimization, so you should probably turn off the post-docking minimization to keep the rings planar.

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