Biologics 2024
Date & Time - March 13th-15th, 2024
Location - London, United Kingdom
Europe’s premier platform for key opinion leaders to discuss the latest innovations & technological advancements in biologics discovery & development.
Schrödinger is excited to be participating in the Biologics 2024 conference taking place on March 13th – 15th in London, United Kingdom. Join us for a workshop by Cindy Gerson, Lead Product Manager at Schrödinger, titled “Computational approaches for engineering peptides and proteins with enhanced properties.” Stop by booth #49 to speak with Schrödinger scientists.
Workshop: Computational approaches for engineering peptides and proteins with enhanced properties
Presenters: Cindy Gerson, Lead Product Manager, Enterprise Informatics & Schrödinger Team
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Introduction to LiveDesign
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Support of biologics modalities within LiveDesign
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Working with peptide sequence, structures, experimental and in silico data within LiveDesign
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Workflows for examining and identifying therapeutic peptide candidates with desirable properties
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Computational strategies for multiparameter optimisation of protein variants
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Triaging diverse antibodies based on combined experimental and in silico data
This workshop aims to provide valuable insights and practical approaches for leveraging computational methods in the design and optimization of therapeutic modalities.
Cindy Gerson
Lead Product Manager, Enterprise Informatics & Schrödinger Team
Abstract:
The enhancement of existing properties and the introduction of new functionalities are pivotal objectives in the development of therapeutic protein modalities such as peptides, antibodies, T cell receptors and enzymes. Typically, achieving these goals involves iterative rounds of time-consuming directed evolution. However, the incorporation of computational structure-based methods, rooted in physics, can expedite this process by providing reliable predictions for the location and identities of potentially beneficial mutations. This approach resulted in targeted selection of a few productive variants, prioritized for expression, or a smaller enriched library that simplifies variant screening. Our workflow has been seamlessly integrated into the Schrödinger collaborative design platform, LiveDesign. This integration allows for the assimilation of various technologies, expediting the discovery cycle.