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What’s new in the Life Science Schrödinger Suite Release 2025-4

We release new platform usability and technological improvements quarterly.

  • Accurately generate, score, and optimize your protein degrader complexes with structure-based in silico workflows (Beta)
  • Enable precise, efficient TCR modeling through a full stack of proven in silico methods
  • Addition of immiscible probes in Mixed Solvent MD to better identify cryptic pockets
  • Expansion of drug formulations applicability with highly accurate Z’=2 polymorph predictions (Beta)
Release notes

What’s new in the Materials Science Schrödinger Suite Release 2025-4

We release new platform usability and technological improvements quarterly.

  • Automated mapping for coarse-grained protein models
  • Model building solution for complex bilayers
  • Predictive solution for ionic conductivity
  • Expanded support for machine learning force fields (MLFF)
  • Support for Universal Models for Atoms (UMA)
Release notes

Interested in downloading PyMOL?

PyMOL is a user-sponsored molecular visualization system on an open-source foundation, maintained and distributed by Schrödinger.

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System Requirements

View all system requirements for Linux, Windows, Mac installations and supported GPU hardware.