Comprehensive modeling platform for biologics discovery

Unlock the possibilities of biologics design

Unlock the possibilities of biologics design

Maestro BioLuminate is Schrödinger’s comprehensive user interface to streamline computationally-guided biologics drug discovery. By leveraging industry-leading molecular simulations and logically organizing tasks and workflows, BioLuminate provides predictive methods to optimize properties of biomolecules from sequence to structure.


Design better quality biomolecules with a comprehensive, user-friendly platform

Build & Model

  • Easily build accurate structural models which serve as key starting points for rational design of biologics
  • Model antibody structures using a fully guided, specialized workflow incorporating de novo CDR loop sampling
  • Leverage advanced protein sequence analysis tools, including annotation capabilities

Predict & Analyze

  • Access cutting-edge, predictive computational modeling workflows for biologics discovery within a streamlined portal
  • Predict and analyze protein-protein or protein-nucleic acid interactions at the atomic level using computational workflows
  • Calculate descriptors for characterizing and triaging antibodies and proteins, including protein surface properties and aggregation propensity

Design & Engineer

  • Enumerate potential amino acid substitutions and design focused libraries
  • Perform in silico mutagenesis to engineer novel variants with superior binding affinity, selectivity, and thermostability
  • Design flexible linkers and rigid linkers to generate multi-functional fusion proteins

Broad application across protein-based therapeutics discovery

Access refined workflows across multiple biological modalities

Antibody Design

Rationally design potent, safe, and developable monoclonal antibodies

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Peptide Discovery

Design peptidic drugs using in silico structure-based methods

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Enzyme Engineering

Efficiently optimize enzymes using structure-based design methods

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Featured CourseAntibody Modeling Online Course

Learn how to use BioLuminate for antibody engineering with our hands-on, online certification course

Level-up your computational modeling skills and enroll in our online course, Introduction to Computational Antibody Engineering.

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Discover how Schrödinger technology is being used to solve real-world research challenges.

Design and optimization of biologics driven by physics-based computational modeling

Antibody modeling with the Schrödinger platform

Enzymes by design: Structure-based methods for modeling enzymes

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Browse the list of peer-reviewed publications using Schrödinger technology in related application areas.

Life Science
Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies
Life Science
Disulfide Bond Engineering of an Endoglucanase from Penicillium verruculosum to Improve Its Thermostability
Life Science
A novel method for in silico assessment of Methionine oxidation risk in monoclonal antibodies: Improvement over the 2-shell model
Life Science
A Descriptor Set for Quantitative Structure-Property Relationship Prediction in Biologics
Life Science
Accurate Prediction of Protein Thermodynamic Stability Changes upon Residue Mutation using Free Energy Perturbation
Life Science
Large-Scale In Vitro Functional Testing and Novel Variant Scoring via Protein Modeling Provide Insights Into Alkaline Phosphatase Activity in Hypophosphatasia
Life Science
AggScore: Prediction of aggregation-prone regions in proteins based on the distribution of surface patches
Life Science
Predicting mutations deleterious to function in beta-lactamase TEM1 using MM-GBSA
Life Science
Relative Binding Affinity Prediction of Charge-Changing Sequence Mutations with FEP in Protein-Protein Interfaces
Life Science
Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1

Training & Resources

Online certification courses

Level up your skill set with hands-on, online molecular modeling courses. These self-paced courses cover a range of scientific topics and include access to Schrödinger software and support.


Learn how to deploy the technology and best practices of Schrödinger software for your project success. Find training resources, tutorials, quick start guides, videos, and more.