- Quick Reference Sheet
GlideMap
A one-page guide to using the GlideMap GUI for ligand placement guided by experimental density.
- Quick Reference Sheet
Synthesis Queue LiveReport
Use Freeform columns to track the status of compounds in a synthesis queue.
- Quick Reference Sheet
Modeling Queue LiveReport
Learn how to use Freeform columns and an Auto-Update Search to create compound progression workflows.
- Quick Reference Sheet
Group Meeting LiveReport
Develop a workflow to allow individuals to triage ideas for group discussion and decision making.
- Quick Reference Sheet
GPU Similarity Tool
Search external databases for similar purchasable compounds.
- Quick Reference Sheet
Matrix Widget
Use this widget to display rich datasets in a dense grid with flexible axis options.
- Quick Reference Sheet
Seed Expansion Plot
Learn how to use LiveDesign to plot the results of a seed or hit expansion.
- Quick Reference Sheet
R-Group Enumeration in LiveDesign
Explore the chemical space around a scaffold using R-group libraries.
- Quick Reference Sheet
Reaction-Based Enumeration to Create Virtual Libraries
Create virtual libraries via reaction-based enumeration.
- Quick Reference Sheet
Generic Entity in LiveDesign
Import various file types into a LiveReport and add data and properties from the file.
- Quick Reference Sheet
Advanced Structural Queries and SAR Techniques
Learn advanced approaches to structure querying in LiveDesign
Case Studies
Case Study
Life Science
Materials Science
Case Study
Life Science
Case Study
Life Science
Documentation
- Documentation
Learning Path: Oligonucleotide Modeling
A structured overview of tools and workflows for nucleic acids in drug discovery.
- Documentation
WaterMap
Efficiently converged MD simulations are run with explicit water molecules, and resultant trajectories are analyzed to cluster hydration sites.
- Documentation
SiteMap
Identify binding sites, including allosteric binding sites and protein-protein interfaces, and evaluate their druggability.
Events
Event
Materials Science
- Dec 8th-11th, 2025
AABC 2025
Schrödinger is excited to be participating in the AABC 2025 conference taking place on December 8th – 11th in Las Vegas, Nevada.
Webinar
Life Science
- Dec 9, 2025
Designing better biologics: A blueprint for leveraging in silico methods in biologics R&D EU
In this exclusive webinar, our experts will provide a technical overview of our unique, physics-based approach to protein engineering and customizable in silico workflow, and discuss several relevant examples.
Webinar
Life Science
- Dec 10, 2025
Scaling FEP+ for success: Strategic deployment of FEP+ and AI/ML to accelerate chemical space exploration
Join us to map out your strategy for maximizing the organizational impact of FEP+ and to achieve the full potential of your computational drug discovery and business goals.
Training Videos
Video
Life Science
Getting Going with Maestro BioLuminate
A free video series introducing the basics of using Maestro Bioluminate.
Video
Life Science
- Video
Introducing Ligand Designer
An overview of the LigandDesigner workflow, Editing in 2D and 3D, using display options and overlays, and accessing the Admin Panel.
Publications
- Publication
- Oct 13, 2025
Accelerated in silico discovery of SGR-1505: A potent MALT1 allosteric inhibitor for the treatment of mature B-cell malignancies
Nie Z, et al. J. Med. Chem., 2025
- Publication
- Oct 12, 2025
Discovery of highly potent noncovalent inhibitors of SARS-CoV-2 main protease through computer-aided drug design
Okabe A, et al. J Med Chem, 2025
- Publication
- Sep 17, 2025
Accurate hydration free energy calculations for diverse organic molecules with a machine learning force field
Xie, et al. ChemRxiv, 2025, 1, Preprint
Quick Reference Sheets
- Quick Reference Sheet
GlideMap
A one-page guide to using the GlideMap GUI for ligand placement guided by experimental density.
- Quick Reference Sheet
Synthesis Queue LiveReport
Use Freeform columns to track the status of compounds in a synthesis queue.
- Quick Reference Sheet
Modeling Queue LiveReport
Learn how to use Freeform columns and an Auto-Update Search to create compound progression workflows.
Tutorials
- Tutorial
Structure-Based Virtual Screening using Glide
Prepare receptor grids for docking, dock molecules and examine the docked poses.
- Tutorial
Ligand Binding Pose Prediction for FEP+
Generate starting poses for FEP simulations for a series of BACE1 inhibitors using core constrained docking.
- Tutorial
Antibody Visualization and Modeling in BioLuminate
Visualize, build, and evaluate antibody models, analyze an antibody for various characteristics, dock an antigen to an antibody.
Webinars
Webinar
Life Science
- Dec 9, 2025
Designing better biologics: A blueprint for leveraging in silico methods in biologics R&D EU
In this exclusive webinar, our experts will provide a technical overview of our unique, physics-based approach to protein engineering and customizable in silico workflow, and discuss several relevant examples.
Webinar
Life Science
- Dec 10, 2025
Scaling FEP+ for success: Strategic deployment of FEP+ and AI/ML to accelerate chemical space exploration
Join us to map out your strategy for maximizing the organizational impact of FEP+ and to achieve the full potential of your computational drug discovery and business goals.
Webinar
Life Science
- Dec 16, 2025
Predictive toxicology solutions: Actionable, structure-based insights to dial-out tox liabilities early
Join us to see how our new Predictive Toxicology Solutions fundamentally change the design process.
White Papers
White Paper
Life Science
- Oct 29, 2024
20 Years of Glide: A Legacy of Docking Innovation and the Next Frontier with Glide WS
Glide has long set the gold standard for commercial molecular docking software due to its robust performance in both binding mode prediction and empirical scoring tasks, ease of use, and tight integration with Schrödinger’s Maestro interface and molecular discovery workflows.
White Paper
Life Science
White Paper
Life Science
Latest insights from Extrapolations blog
With FEP+, “The Experiment is the Limit.”
Over the past century, small molecule drugs have represented the dominant modality in drug research, enabling medical breakthroughs that have saved countless lives.
Tackling Drug Solubility: AbbVie and Schrödinger Collaborate to Advance Accurate Prediction Methods
The complexity and size of drug candidates has grown in recent years as scientists pursue novel targets once considered undruggable.
Blog
Can AlphaFold Models be Used for Structure-Based Drug Design? A Perspective Two Years In
We recently sat down with Edward Miller, Senior Director of Protein Structure Modeling at Schrödinger, to discuss his experience using AlphaFold models for SBDD.
Training & Resources
Online certification courses
Level up your skill set with hands-on, online molecular modeling courses. These self-paced courses cover a range of scientific topics and include access to Schrödinger software and support.
Free learning resources
Learn how to deploy the technology and best practices of Schrödinger software for your project success. Find training resources, tutorials, quick start guides, videos, and more.
Other Resources