Discovery on Target 2024
Date & Time - September 30th – October 3rd, 2024
Location - Boston, Massachusetts
Schrödinger is excited to be participating in the Discovery on Target 2024 conference taking place on September 30th – October 3rd in Boston, Massachusetts. Join us for a poster by Shelby Ellery, Principal Scientist II at Schrödinger, titled “Discovery of first-in-class highly selective Wee2 inhibitors.” Stop by booth #523 to speak with Schrödinger scientists.
Speaker:
Shelby Ellery, Principal Scientist II, Schrödinger
Abstract:
Selective Wee2 kinase inhibitors could address the unmet need for non-hormonal contraception.
In this poster, we describe the identification and further optimization of potent and selective Wee2 inhibitors. Our orthosteric series was improved by using prospective FEP+. In collaboration with HitGen, a DEL screen identified potent allosteric inhibitors. The allosteric series show exquisite kinome selectivity and target engagement in ex vivo mouse oocyte assays.