Festival of Biologics 2025
Date & Time - April 23rd-24th, 2025
Location - San Diego, California
Schrödinger is excited to be participating in the Festival of Biologics 2025 conference taking place on April 23rd – 24th in San Diego, California. Join us for a poster presentation by Zhe Mei, Senior Scientist I at Schrödinger, titled “Antibody Optimization with Physics based and Machine Learning based modeling.” Stop by booth #835 to speak with Schrödinger scientists.
6:10 PM Antibody Optimization with Physics based and Machine Learning based modeling
Speaker:
Zhe Mei, Senior Scientist I, Schrödinger
Abstract:
Optimizing antibody properties, such as binding affinity, stability and aggregation is crucial for developing safe and effective biotherapeutics. This work presents an integrated approach leveraging physics-based modeling and machine learning to address these challenges. We use both methods to predict 3D structures and calculate a rich set of sequence-based, structure-based and surface patch-based protein descriptors that can be used to train machine learning models. Further, we can identify hotspots for targeted optimization of stability and affinity and apply physics-based methods like free energy perturbation (FEP+) to design improved and developable variants.