GGMM 2025 – Young Modellers Conference

Leveraging computational methods for protein engineering

Speaker:
Jelena Vucinic, Senior Scientist I, Schrödinger

Abstract:
The landscape of protein engineering is evolving rapidly, driven by cutting-edge computational techniques that are transforming biopharmaceutical discovery and optimization. Engineering biologic drug candidates to optimize desirable properties or reduce unwanted characteristics often requires extensive experimentation. In this talk, we will explore groundbreaking methods that enable accurate modeling of critical physical endpoints, including thermal stability, protein-protein binding affinity, pH sensing profiles and developability risks. These innovations promise to accelerate early-stage discovery while enhancing the precision of biotherapeutic design. We will highlight recent advances in computational structure-based methods and their role in expediting candidate optimization.