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Improved Methods for Side Chain and Loop Predictions via the Protein Local Optimization Program: Variable Dielectric Model for Implicitly Improving the Treatment of Polarization Effects

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in UncategorizedLeave a Comment on Improved Methods for Side Chain and Loop Predictions via the Protein Local Optimization Program: Variable Dielectric Model for Implicitly Improving the Treatment of Polarization Effects

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Informatics and Team Collaboration, Structure Prediction & Target EnablementLeave a Comment on Molecular determinants of selectivity and efficacy at the dopamine D3 receptor

PIPER: An FFT-based protein docking program with pairwise potentials

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in UncategorizedLeave a Comment on PIPER: An FFT-based protein docking program with pairwise potentials

DARS (Decoys As the Reference State) Potentials for Protein-Protein Docking

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Hit DiscoveryLeave a Comment on DARS (Decoys As the Reference State) Potentials for Protein-Protein Docking

The 4th meeting on the Critical Assessment of Predicted Interaction (CAPRI) held at the Mare Nostrum, Barcelona

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Structure Prediction & Target EnablementLeave a Comment on The 4th meeting on the Critical Assessment of Predicted Interaction (CAPRI) held at the Mare Nostrum, Barcelona

Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in UncategorizedLeave a Comment on Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling

E-Pharmacophore mapping and docking studies on Vitamin D receptor (VDR)

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Hit Discovery, Informatics and Team CollaborationLeave a Comment on E-Pharmacophore mapping and docking studies on Vitamin D receptor (VDR)

Identification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (part I): Virtual screening and activity assays

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Hit Discovery, Hit-to-Lead & Lead OptimizationLeave a Comment on Identification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (part I): Virtual screening and activity assays

The role of tyrosine 177 in human 11′-hydroxysteroid dehydrogenase type 1 in substrate and inhibitor binding: an unlikely hydrogen bond donor for the substrate

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in UncategorizedLeave a Comment on The role of tyrosine 177 in human 11′-hydroxysteroid dehydrogenase type 1 in substrate and inhibitor binding: an unlikely hydrogen bond donor for the substrate

Development and Testing of the OPLS All-Atom Force Field on Conformational Energetics and Properties of Organic Liquids

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Hit-to-Lead & Lead OptimizationLeave a Comment on Development and Testing of the OPLS All-Atom Force Field on Conformational Energetics and Properties of Organic Liquids

Role of the active-site solvent in the thermodynamics of factor Xa ligand binding

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Hit Discovery, Structure Prediction & Target EnablementLeave a Comment on Role of the active-site solvent in the thermodynamics of factor Xa ligand binding

Mixed Quantum Mechanical/ Molecular Mechanical (QM/MM) Study of the Deacylation Reaction in a Penicillin Binding Protein (PBP) Versus in a Class C ‘-Lactamase

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in UncategorizedLeave a Comment on Mixed Quantum Mechanical/ Molecular Mechanical (QM/MM) Study of the Deacylation Reaction in a Penicillin Binding Protein (PBP) Versus in a Class C ‘-Lactamase

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