Discovery of’ 3-[2- (Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3- (trifluoromethyl)phenyl] benzamide (AP24534), a Potent, Orally Active Pan-Inhibitor of Breakpoint Cluster Region-Abelson (BCR-ABL) Kinase Including the T315I Gatekeeper Mutant Posted on September 8, 2015December 13, 2024 by Anonymous
Position 5.46 of the Serotonin 5-HT2A Receptor Contributes to a Species-Dependent Variation for the 5-HT2C Agonist (R)-9-Ethyl-1,3,4,10b-tetrahydro-7- trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one: Impact on Selectivity and Toxicological Evaluation Posted on September 8, 2015December 13, 2024 by Anonymous
Differential estrogen receptor subtype modulators: Assessment of estrogen receptor subtype-binding selectivity and transcription-regulating properties of new cycloalkyl pyrazoles Posted on September 8, 2015December 13, 2024 by Anonymous
In silico binding free energy predictability by using the linear interaction energy (LIE) method: bromobenzimidazole CK2 inhibitors as a case study Posted on September 8, 2015December 13, 2024 by Anonymous
Amide-based inhibitors of p38′ MAP kinase. Part 1: Discovery of novel N-pyridyl amide lead molecules Posted on September 8, 2015December 13, 2024 by Anonymous
P2Y1 antagonists: combining receptor-based modeling and QSAR for a quantitative prediction of the biological activity based on consensus scoring Posted on September 8, 2015December 13, 2024 by Anonymous
1H-1,2,3-Triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors Posted on September 8, 2015December 13, 2024 by Anonymous
MM-GB/SA Rescoring of Docking Poses in Structure-Based Lead Optimization Posted on September 8, 2015December 13, 2024 by Anonymous
Novel selective human melanocortin-3 receptor ligands: use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold Posted on September 8, 2015December 13, 2024 by Anonymous
NADH Oxidase Activity of Bacillus subtilis Nitroreductase NfrA1: Insight into its Biological Role Posted on September 8, 2015December 13, 2024 by Anonymous
Analysis and Comparison of 2D Fingerprints: Insights into Database Screening Performance Using Eight Fingerprint Methods Posted on September 8, 2015December 13, 2024 by Anonymous
Thyrotropin-releasing hormone and its receptors–a hypothesis for binding and receptor activation Posted on September 8, 2015December 13, 2024 by Anonymous