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PHASE: A Novel Approach to Pharmacophore Modeling and 3D Database Searching

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Hit Discovery, Informatics and Team CollaborationLeave a Comment on PHASE: A Novel Approach to Pharmacophore Modeling and 3D Database Searching

Novel inverse binding mode of indirubin derivatives yields improved selectivity for DYRK kinases

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in UncategorizedLeave a Comment on Novel inverse binding mode of indirubin derivatives yields improved selectivity for DYRK kinases

Search for Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Using Chemical Similarity, Molecular Docking, and MM-GB/SA Scoring

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Informatics and Team CollaborationLeave a Comment on Search for Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Using Chemical Similarity, Molecular Docking, and MM-GB/SA Scoring

Dihydropyridopyrazinones and Dihydropteridinones as Corticotropin-Releasing Factor-1 Receptor Antagonists: Structure-Activity Relationships and Computational Modeling

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Informatics and Team CollaborationLeave a Comment on Dihydropyridopyrazinones and Dihydropteridinones as Corticotropin-Releasing Factor-1 Receptor Antagonists: Structure-Activity Relationships and Computational Modeling

Computer-aided drug design of falcipain inhibitors: Virtual screening, structure-activity relationships, hydration site thermodynamics, and reactivity analysis

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Hit Discovery, Hit-to-Lead & Lead OptimizationLeave a Comment on Computer-aided drug design of falcipain inhibitors: Virtual screening, structure-activity relationships, hydration site thermodynamics, and reactivity analysis

Computer-Aided Design of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in UncategorizedLeave a Comment on Computer-Aided Design of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase

Thermodynamic analysis of water molecules at the surface of proteins and applications to binding site prediction and characterization

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Hit-to-Lead & Lead OptimizationLeave a Comment on Thermodynamic analysis of water molecules at the surface of proteins and applications to binding site prediction and characterization

Solution-Phase Synthesis of a Tricyclic Pyrrole-2-Carboxamide Discovery Library Applying a Stetter-Paal-Knorr Reaction Sequence

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Structure Prediction & Target EnablementLeave a Comment on Solution-Phase Synthesis of a Tricyclic Pyrrole-2-Carboxamide Discovery Library Applying a Stetter-Paal-Knorr Reaction Sequence

Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in UncategorizedLeave a Comment on Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase

Influence of Molecular Flexibility and Polar Surface Area Metrics on Oral Bioavailability in the Rat

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Informatics and Team CollaborationLeave a Comment on Influence of Molecular Flexibility and Polar Surface Area Metrics on Oral Bioavailability in the Rat

Rational approaches to improving selectivity in drug design

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in UncategorizedLeave a Comment on Rational approaches to improving selectivity in drug design

QSAR Studies of PC-3 Cell Line Inhibition Activity of TSA and SAHA-like Hydroxamic Acids

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Informatics and Team CollaborationLeave a Comment on QSAR Studies of PC-3 Cell Line Inhibition Activity of TSA and SAHA-like Hydroxamic Acids

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