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Assignment of Polar States for Protein Amino Acid Residues Using an Interaction Cluster Decomposition Algorithm and its Application to High Resolution Protein Structure Modeling

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Informatics and Team CollaborationLeave a Comment on Assignment of Polar States for Protein Amino Acid Residues Using an Interaction Cluster Decomposition Algorithm and its Application to High Resolution Protein Structure Modeling

Addressing limitations with the MM-GB/SA scoring procedure using the WaterMap method and free energy perturbation calculations

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Hit-to-Lead & Lead OptimizationLeave a Comment on Addressing limitations with the MM-GB/SA scoring procedure using the WaterMap method and free energy perturbation calculations

Homology models of dipeptidyl peptidases 8 and 9 with a focus on loop predictions near the active site

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in UncategorizedLeave a Comment on Homology models of dipeptidyl peptidases 8 and 9 with a focus on loop predictions near the active site

Hydration site thermodynamics explain SARs for Triazolylpurines Analogues Binding to the A2A Receptor

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Hit-to-Lead & Lead OptimizationLeave a Comment on Hydration site thermodynamics explain SARs for Triazolylpurines Analogues Binding to the A2A Receptor

Conformational Changes in Protein Loops and Helices Induced by Post-Translational Phosphorylation

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in UncategorizedLeave a Comment on Conformational Changes in Protein Loops and Helices Induced by Post-Translational Phosphorylation

Computational analysis of phosphopeptide binding to the polo-box domain of the mitotic kinase PLK1 using molecular dynamics simulation

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Hit-to-Lead & Lead OptimizationLeave a Comment on Computational analysis of phosphopeptide binding to the polo-box domain of the mitotic kinase PLK1 using molecular dynamics simulation

New hypotheses about the structure-function of proprotein convertase subtilisin/kexin type 9: Analysis of the epidermal growth factor-like repeat A docking site using WaterMap

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Hit-to-Lead & Lead OptimizationLeave a Comment on New hypotheses about the structure-function of proprotein convertase subtilisin/kexin type 9: Analysis of the epidermal growth factor-like repeat A docking site using WaterMap

Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: Successful in silico prediction of the relative permeabilities of cyclic peptides

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in UncategorizedLeave a Comment on Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: Successful in silico prediction of the relative permeabilities of cyclic peptides

Understanding kinase selectivity through energetic analysis of binding site waters

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in UncategorizedLeave a Comment on Understanding kinase selectivity through energetic analysis of binding site waters

Accurate Prediction of the Relative Potencies of Members of a Series of Kinase Inhibitors Using Molecular Docking and MM-GBSA Scoring

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Structure Prediction & Target EnablementLeave a Comment on Accurate Prediction of the Relative Potencies of Members of a Series of Kinase Inhibitors Using Molecular Docking and MM-GBSA Scoring

High-energy water sites determine peptide binding affinity and specificity of PDZ domains

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Hit-to-Lead & Lead OptimizationLeave a Comment on High-energy water sites determine peptide binding affinity and specificity of PDZ domains

First-Shell Solvation of Ion Pairs: Correction of Systematic Errors in Implicit Solvent Models

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in UncategorizedLeave a Comment on First-Shell Solvation of Ion Pairs: Correction of Systematic Errors in Implicit Solvent Models

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