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Channelrhodopsin-2 function is modulated by residual hydrophobic mismatch with the surrounding lipid environment

Posted on September 19, 2019January 23, 2025 by Anonymous
Posted in Biologics Drug DiscoveryLeave a Comment on Channelrhodopsin-2 function is modulated by residual hydrophobic mismatch with the surrounding lipid environment

Conformational communication mediates the reset step in t6A biosynthesis

Posted on September 19, 2019January 23, 2025 by Anonymous
Posted in Biologics Drug DiscoveryLeave a Comment on Conformational communication mediates the reset step in t6A biosynthesis

Promoting transparency and reproducibility in enhanced molecular simulations

Posted on September 19, 2019January 23, 2025 by Anonymous
Posted in Small Molecule Drug DiscoveryLeave a Comment on Promoting transparency and reproducibility in enhanced molecular simulations

Two PKA RI’ holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP

Posted on September 19, 2019January 23, 2025 by Anonymous
Posted in Small Molecule Drug DiscoveryLeave a Comment on Two PKA RI’ holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP

Molecular simulation driven experiment for formulation of fixed dose combination of Darunavir and Ritonavir as anti-HIV nanosuspension

Posted on September 19, 2019January 23, 2025 by Anonymous
Posted in Small Molecule Drug DiscoveryLeave a Comment on Molecular simulation driven experiment for formulation of fixed dose combination of Darunavir and Ritonavir as anti-HIV nanosuspension

Rigorous Free Energy Perturbation Approach to Estimating Relative Binding Affinities between Ligands with Multiple Protonation and Tautomeric States

Posted on September 17, 2019January 23, 2025 by Anonymous
Posted in Hit-to-Lead & Lead OptimizationLeave a Comment on Rigorous Free Energy Perturbation Approach to Estimating Relative Binding Affinities between Ligands with Multiple Protonation and Tautomeric States

Protein-Ligand Binding Free Energy Calculations with FEP+

Posted on September 17, 2019December 10, 2024 by Anonymous
Posted in Hit-to-Lead & Lead OptimizationLeave a Comment on Protein-Ligand Binding Free Energy Calculations with FEP+

Noncovalent inhibitors reveal BTK gatekeeper and auto-inhibitory residues that control its transforming activity

Posted on September 17, 2019December 10, 2024 by Anonymous
Posted in Hit-to-Lead & Lead OptimizationLeave a Comment on Noncovalent inhibitors reveal BTK gatekeeper and auto-inhibitory residues that control its transforming activity

Generation of Tautomers Using Micro-pKa-s

Posted on July 22, 2019January 23, 2025 by Anonymous
Posted in Small Molecule Drug DiscoveryLeave a Comment on Generation of Tautomers Using Micro-pKa-s

Effects of Lewis Acidic Metal Ions (M) on Oxygen-Atom Transfer Reactivity of Heterometallic Mn3MO4 Cubane and Fe3MO(OH) and Mn3MO(OH) Clusters

Posted on June 28, 2019December 10, 2024 by Anonymous
Posted in Catalysis & ReactivityLeave a Comment on Effects of Lewis Acidic Metal Ions (M) on Oxygen-Atom Transfer Reactivity of Heterometallic Mn3MO4 Cubane and Fe3MO(OH) and Mn3MO(OH) Clusters

Low-temperature, high-growth-rate ALD of SiO2 using aminodisilane precursor

Posted on June 28, 2019December 10, 2024 by Anonymous
Posted in Thin Film ProcessingLeave a Comment on Low-temperature, high-growth-rate ALD of SiO2 using aminodisilane precursor

Understanding molecular fragmentation in blue phosphorescent organic light-emitting devices

Posted on June 28, 2019December 10, 2024 by Anonymous
Posted in Organic ElectronicsLeave a Comment on Understanding molecular fragmentation in blue phosphorescent organic light-emitting devices

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