Prime
A powerful and innovative solution for accurate protein structure prediction
Overview
Prime is a fully-integrated protein structure prediction solution that incorporates homology modeling and fold recognition into a single solution. Prime includes an intuitive step-by-step interface that takes users through the workflow of structure prediction by supplying helpful default settings for each stage of the process.
Webinars
Discover how Schrödinger technology is being used to solve real-world research challenges.
Homology modeling with the Schrödinger Biologics Suite
Antibody modeling with the Schrödinger Platform
Key Capabilities
Refine experimental structures obtained through X-ray crystallography, NMR or Cryo-EM for accurate and detailed starting points for subsequent simulations
Accurately predict protein structures from sequence to obtain a high-quality model when an experimental structure is not available
Predict and refine side chain positions to create a complete, all-atom protein mode.
Predict membrane permeability and conformations of macrocycles
Rapidly calculate energetics system of interest using MM-GBSA
Benefit from an intuitive step-by-step interface that takes users through the full workflow of structure prediction
Create backbone models for early structural investigations or functional annotation in cases of low- or no-sequence identity
Rapidly scan thousands of protein mutations, with tight integration to FEP+ that allows for an accurate and thorough screening cascade for protein optimization.
Documentation & Tutorials
Get answers to common questions and learn best practices for using Schrödinger’s software.
Related Products
Learn more about the related computational technologies available to progress your research projects.
IFD-MD
Accurate ligand binding mode prediction for novel chemical matter, for on-targets and off-targets
Membrane Permeability
Physics-based solution for rapid and accurate prediction of passive membrane permeability
Publications
Browse the list of peer-reviewed publications using Schrödinger technology in related application areas.
Training & Resources
Online certification courses
Level up your skill set with hands-on, online molecular modeling courses. These self-paced courses cover a range of scientific topics and include access to Schrödinger software and support.
Tutorials
Learn how to deploy the technology and best practices of Schrödinger software for your project success. Find training resources, tutorials, quick start guides, videos, and more.
Other Resources