RetroSynth

From design to synthesis, faster and cheaper
RetroSynth is the AI-driven synthesis planning platform engineered to rapidly predict optimal, highly accurate, and cost-efficient synthetic pathways that accelerate your lead optimization at a fraction of the time and cost.

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Designing the best molecule is just the first step, we give you the keys to synthesizing it*

Savings on synthesis cost

Faster synthesis turnaround time

Faster DMTA cycles

Query billions of building blocks

Tap into real-time building block intelligence delivering tractable routes based on the availability of internal and commercial precursors

Predict and identify actionable routes

Accurately generate and score thousands of optimal, plausible routes to deliver the most optimal synthetic routes directly to the bench

Identify reliable, short, and efficient synthesis routes

Eliminate the bottleneck of manual route planning and dramatically reduce project spend by minimizing the need for expensive, multi-stage custom synthesis

Accelerated go/no-go decisions

Only invest resources in compounds with the highest probability of successful synthesis by using AI-powered forward reaction verification

Featured Webinar

Life Science
Webinar

Scaling FEP+ for Success: Strategic deployment of FEP+ and AI/ML to accelerate chemical space exploration

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Discover the benefits of RetroSynth

Capability	Description	Benefits
Accurate route planning	AI-powered forward reaction verification coupled with in-house custom scoring	Ensures that every suggested route is plausible and bench-ready
Real-time building block intelligence	Query billions of building blocks in real-time	Actionable routes based on the immediate availability of internal and commercial precursors
Massive scale and performance	Distributed cloud-native MCTS architecture and Kubernetes infrastructure allow you to complete 100,000+ ideas in 24 hours at a low compute cost	Rapid exploration of ultra-large chemical spaces without sacrificing accuracy

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Training & Resources

Online certification courses

Level up your skill set with hands-on, online molecular modeling courses. These self-paced courses cover a range of scientific topics and include access to Schrödinger software and support.

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Tutorials

Learn how to deploy the technology and best practices of Schrödinger software for your project success. Find training resources, tutorials, quick start guides, videos, and more.

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Other Resources

*Data from active internal Schrödinger’s therapeutics group discovery programs