We would like to keep you informed of upcoming changes to our tools and infrastructure that may require action from your IT team. See the table below for a list of anticipated changes and please note the first release that will be affected by each. For queries or concerns regarding these changes please email help@schrodinger.com.
| Feature Change | Description/Notes | Affected Release |
|
CUDA 13 upgrade |
GPU compute nodes and workstations will need a CUDA 13.x-compatible NVIDIA driver (>= 580.XX.YY) installed to run our GPU-enabled products starting in release 27-1. As a result of this CUDA upgrade, running calculations on Pascal (Tesla P40, Tesla P100, Quadro P5000) and Volta (V100) architecture GPUs will no longer work in release 27-1. | 27-1 |
|
Volta GPU Architecture Deprecation |
Support for all Volta architecture GPU cards is deprecated starting in the 26-4 release. We still expect our software to run on this architecture until we upgrade to CUDA 13 (see note above). If you still rely on Volta GPU cards for computation for the Schrödinger Suite, we recommend exploring newer options. | 26-4 |
| Deprecation of Job Control | Legacy Job Control is officially deprecated in release 26-4, and Job Server is now our only officially supported job submission system. Job Control is now provided on a ‘use at your own risk’ basis and may be removed without notice if breaking issues arise. Customers must migrate to Job Server to ensure uninterrupted service. | 26-4 |
| Native ARM Support for Mac & macOS 15 Recommendation | Starting with release 26-4, our software will run natively on Apple Silicon (ARM) processors rather than relying on emulation via Rosetta. Please note that as a result of this transition, the software will no longer install or run on Intel-based (x86) Macs.
Moreover, to ensure full compatibility with required math libraries, we strongly recommend updating to macOS 15 (Sequoia) or higher. Users running 26-4 on macOS 14 or lower may experience unpredictable parallelization in certain linear algebra operations. |
26-4 |
| Pascal GPU Architecture Deprecation | Support for all Pascal architecture GPU cards (Tesla P40, Tesla P100, and Quadro P5000) is deprecated starting in the 26-3 release. We still expect our software to run on this architecture until we upgrade to CUDA 13 (see note above). If you still rely on Pascal GPU cards for computation for the Schrödinger Suite, we recommend exploring newer options. | 26-3 |
| CUDA Library upgrade | GPU compute nodes and workstations will require an Nvidia driver compatible with CUDA 12.9 (>= 575.51.03) to run our GPU-enabled products. This upgrade is mandatory to enable support for the OPLS5 force field and ensure compatibility with the latest generation of Nvidia hardware. | 26-2 |
| Deprecation of Intel-based (x86) Mac Support | Starting with version 26-2, the installation of our software on Intel-based (x86) Mac systems is officially deprecated. We strongly recommend transitioning to Apple Silicon (ARM64)-based systems to ensure compatibility and optimal performance with all future release versions. | 26-2 |
| Drop support for Windows 10 | Windows 10 will no longer be officially supported after Release 2025-3, which coincides with the end of official Windows 10 support in mid-October 2025. | 25-4 |
| Drop support for MacOS 13 (Ventura) | MacOS 13 (Ventura) will no longer be supported from release 2025-4 onwards. | 25-4 |
| Job Server on by default | Starting in 2025-4, Schrödinger software will use Job Server by default. Customers who currently use Job Control will need to deploy and configure Job Server alongside legacy Job Control infrastructure to ensure minimal disruption. Single-node Linux machines can transition quickly and easily with the Job Server Quick Install Script. For cluster configuration, see Job Server Installation. | 25-4 |
| Job Server transitions to centralized host configuration | Starting in 2025-3 Schrödinger’s Job Server will switch to a centralized host configuration. Existing Customers who use Job Server for job submission and will be updating client submission machines with the Schrödinger release 2025-3 will be need to update the Job Server configuration file used for Schrodinger jobs. Learn more about Centralization of Job Servers Compute Host Configuration. | 25-3 |
| FlexNet licensing no longer supported | Schrödinger License Manager will be the only licensing system used by Schrödinger software as of the 25-1 release. We will no longer be issuing FlexNet licenses at this point. | 25-1 |
| Schrödinger License Manager will be on by default | Schrödinger software release will use Schrödinger License Manager by default.
FlexNet licensing can be used with the 2024-3 release. See 2024-3 FlexNet Licensing Instructions here. |
24-3 |
| Drop support for RHEL/CentOS 7 | RHEL/CentOS 7 will reach their end of life on June 30, 2024 and will no longer be supported after release 24-2. | 24-3 |
| Schrödinger License Manager introduced | Schrödinger License Manager is made available to customers interested in transitioning to new licensing system. | 24-2 |
| Drop support for SUSE 12/15 | Due to limited use by customers and short support cycle lifetimes for SUSE service packs we are aiming to deprecate SUSE support and concentrate our testing, support and development resources on our other supported Linux OSs. | 24-2 |
| MacOS 10.x installers | Official support for the last MacOS 10.x-based version ended with release 2023-1. Starting with release 2024-1, our software installer won’t run on MacOS versions lower than MacOS 11. | 24-1 |
| CUDA Library upgrade | Schrödinger Suite: GPU compute nodes and workstations will need a CUDA 12.0 (>= 525.60.13) compatible Nvidia driver installed to run our GPU enabled products. This upgrade is required to support the latest generations of Nvidia GPUs (Hopper and Lovelace). | 23-3 |
| Support for SSE4.2 | From release 2023-3 onwards our software requires support for the SSE4.2 CPU instruction set. Please see KB Article 243079 for more information. | 23-3 |
| Rocky Linux (CentOS 8) | The 21-4 release will be the last to support CentOS 8. With RedHat’s announcement that they will not provide updates for CentOS 8 after 2021 we are switching to testing and supporting Rocky Linux from the 22-1 release onwards. We will continue to support CentOS 7 throughout its lifecycle. | 21-4 |