Speaker:

Abhijit Kayal, Senior Scientist II, Schrödinger

Abstract:

Rational design of biologics, including antibodies and engineered proteins, presents a significant challenge due to the complex interplay of multiple parameters such as stability, binding affinity, selectivity, immunogenicity, and more. Each mutation can differentially influence these properties, making biologics development a high-dimensional, multi-objective optimization problem. In this webinar, we will highlight advanced computational approaches, integrating physics-based simulations to systematically accelerate and streamline the biologics design process. Particular emphasis will be given on strategies for predicting and enhancing protein stability and binding affinity, which are critical determinants of therapeutic efficacy and developability.