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Contributions of water transfer energy to protein-ligand association and dissociation barriers: WaterMap analysis of a series of p38′ MAP kinase inhibitors

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Hit DiscoveryLeave a Comment on Contributions of water transfer energy to protein-ligand association and dissociation barriers: WaterMap analysis of a series of p38′ MAP kinase inhibitors

Rational Design, Synthesis, and Pharmacological Evaluation of 2-Azanorbornane-3-exo,5-endo-dicarboxylic Acid: A Novel Conformationally Restricted Glutamic Acid Analogue

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in UncategorizedLeave a Comment on Rational Design, Synthesis, and Pharmacological Evaluation of 2-Azanorbornane-3-exo,5-endo-dicarboxylic Acid: A Novel Conformationally Restricted Glutamic Acid Analogue

Receptor- and ligand-based study of fullerene analogues: Comprehensive computational approach including quantum-chemical, QSAR and molecular docking simulations

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Informatics and Team CollaborationLeave a Comment on Receptor- and ligand-based study of fullerene analogues: Comprehensive computational approach including quantum-chemical, QSAR and molecular docking simulations

Stereostructure-Activity Studies on Agonists at the AMPA and Kainate Subtypes of Ionotropic Glutamate Receptors

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in UncategorizedLeave a Comment on Stereostructure-Activity Studies on Agonists at the AMPA and Kainate Subtypes of Ionotropic Glutamate Receptors

Illuminating HIV gp120-ligand recognition through computationally-driven optimization of antibody-recruiting molecules

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Hit-to-Lead & Lead OptimizationLeave a Comment on Illuminating HIV gp120-ligand recognition through computationally-driven optimization of antibody-recruiting molecules

Metal-Dependent Inhibition of HIV-1 Integrase

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in UncategorizedLeave a Comment on Metal-Dependent Inhibition of HIV-1 Integrase

Fragment-based hit identification: Thinking in 3D

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Informatics and Team Collaboration, Structure Prediction & Target EnablementLeave a Comment on Fragment-based hit identification: Thinking in 3D

Selective Agonists at Group II Metabotropic Glutamate Receptors: Synthesis, Stereochemistry, and Molecular Pharmacology of (S)- and (R)-2-Amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl) butyric Acid

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in UncategorizedLeave a Comment on Selective Agonists at Group II Metabotropic Glutamate Receptors: Synthesis, Stereochemistry, and Molecular Pharmacology of (S)- and (R)-2-Amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl) butyric Acid

Bioguided discovery and pharmacophore modeling of the mycotoxic indole diterpene alkaloids penitrems as breast cancer proliferation, migration, and invasion inhibitors

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in UncategorizedLeave a Comment on Bioguided discovery and pharmacophore modeling of the mycotoxic indole diterpene alkaloids penitrems as breast cancer proliferation, migration, and invasion inhibitors

Solvent Models for Protein-Ligand Binding: Comparison of Implicit Solvent Poisson and Surface Generalized Born Models with Explicit Solvent Simulations

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Informatics and Team CollaborationLeave a Comment on Solvent Models for Protein-Ligand Binding: Comparison of Implicit Solvent Poisson and Surface Generalized Born Models with Explicit Solvent Simulations

Optimization, Pharmacophore Modeling and 3D-QSAR Studies of Sipholanes as Breast Cancer Migration and Proliferation Inhibitors

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Hit Discovery, Informatics and Team CollaborationLeave a Comment on Optimization, Pharmacophore Modeling and 3D-QSAR Studies of Sipholanes as Breast Cancer Migration and Proliferation Inhibitors

New Linear Interaction Method for Binding Affinity Calculations Using a Continuum Solvent Model

Posted on September 8, 2015December 13, 2024 by Anonymous
Posted in Informatics and Team CollaborationLeave a Comment on New Linear Interaction Method for Binding Affinity Calculations Using a Continuum Solvent Model

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