BioLuminate

Comprehensive modeling platform for biologics discovery

BioLuminate

Unlock the possibilities of biologics design

Maestro BioLuminate is Schrödinger’s comprehensive interface to streamline computationally-guided biologics drug discovery. By leveraging industry-leading molecular simulations and logically organizing tasks and workflows, BioLuminate provides predictive methods to optimize properties of biomolecules from sequence to structure.

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Design better quality biomolecules with a comprehensive, user-friendly platform

Build & Model

  • Easily build accurate structural models which serve as key starting points for rational design of biologics
  • Model antibody structures using a fully guided, specialized workflow incorporating de novo CDR loop sampling
  • Leverage advanced protein sequence analysis tools, including annotation capabilities

Predict & Analyze

  • Access cutting-edge, predictive computational modeling workflows for biologics discovery within a streamlined portal
  • Predict and analyze protein-protein or protein-nucleic acid interactions at the atomic level using computational workflows
  • Calculate descriptors for characterizing and triaging antibodies and proteins, including protein surface properties and aggregation propensity

Design & Engineer

  • Enumerate potential amino acid substitutions and design focused libraries
  • Perform in silico mutagenesis to engineer novel variants with superior binding affinity, selectivity, and thermostability
  • Design flexible linkers and rigid linkers to generate multi-functional fusion proteins

Broad application across protein-based therapeutics discovery

Access refined workflows across multiple biological modalities

Antibody Design

Rationally design potent, safe, and developable monoclonal antibodies

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Peptide Discovery

Design peptidic drugs using in silico structure-based methods

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Enzyme Engineering

Efficiently optimize enzymes using structure-based design methods

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Documentation & Tutorials

Get answers to common questions and learn best practices for using Schrödinger’s software.

Life Science Documentation

BioLuminate

Schrödinger’s comprehensive modeling platform for biologics discovery.

Life Science Tutorial

Introduction to T Cell Receptor Modeling with BioLuminate

Structure preparation, visualization and analysis of key interactions in the TCR-peptide-MHC complex.

Life Science Tutorial

Antibody Visualization and Modeling in BioLuminate

Visualize, build, and evaluate antibody models, analyze an antibody for various characteristics, dock an antigen to an antibody.

Life Science Tutorial

Identifying impactful mutations using FEP+ residue scanning

Perform an FEP+ residue scan for identifying the impact of mutations on the stability and affinity of a protein-protein system.

Life Science Tutorial

Disulfide Bond Engineering

Run cysteine scanning to identify residues that could be mutated to cysteine to improve thermal stability and facilitate crystallization.

Life Science Tutorial

Heteromultimer Homology Modeling with the Multiple Sequence Viewer/Editor

Build a heteromultimer homology model of human hemoglobin from a bar-head goose hemoglobin structure.

Life Science Tutorial

Peptide Modeling with BioLuminate

Dock peptides to a protein receptor, identify possible binding hotspots, perform lead optimization, and predict binding affinity with QSAR.

Life Science Tutorial

Liability Analysis for Biologics

Explore tools that can be used in liability detection and mitigation for biologics.

Life Science Tutorial

Chimeric Homology Modeling Using the Multiple Sequence Viewer/Editor

Build a chimeric homology model using the Multiple Sequence Viewer/Editor (MSV).

Life Science Tutorial

Sequence Annotation of Antibodies with the Multiple Sequence Viewer/Editor

Annotate an antibody sequence with residue-level properties with the Multiple Sequence Viewer/Editor (MSV).

Featured CourseIntroduction to Computational Antibody Engineering Course

Learn how to use BioLuminate for antibody engineering with our hands-on, online certification course

Level-up your computational modeling skills and enroll in our online course, Introduction to Computational Antibody Engineering.

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Case studies & webinars

Discover how Schrödinger technology is being used to solve real-world research challenges.

Life Science Webinar

MAY 14, 2025 | Schrödinger デジタル創薬セミナー17 | Schrödinger’s approach to physics-based antibody analysis and design

Schrödinger’s approach to physics-based antibody analysis and design

Life Science Webinar

Antibody Humanization Guided by Computational Modeling

Life Science Webinar

Accelerating Antibody Drug Discovery Through Computational Modeling

In this webinar, we provide an overview of computational modeling strategies for antibody design.

Life Science Webinar

生物制药设计 | BioLuminate

本培训我们将演示BioLuminate生物制药设计工作流程,其中包括

Life Science Webinar

Antibody modeling with the Schrödinger Platform

This webinar presents the tools available in BioLuminate to model antibody structures, covering homology modeling, humanization, antigen-antibody docking, liability prediction, and in silico mutations.

Life Science Webinar

Homology modeling with the Schrödinger Biologics Suite

In this webinar, we present a short introduction to homology modeling followed by a a demonstration of how to use Schrödinger tools to build and analyze homology models.

Life Science Webinar

Aggregation scoring and liability prediction using Schrödinger’s Biologics Suite

Publications

Browse the list of peer-reviewed publications using Schrödinger technology in related application areas.

Life Science Publication

Novel druggable space in human KRAS G13D discovered using structural bioinformatics and a P-loop targeting monoclonal antibody

Life Science Publication

Robust prediction of relative binding energies for protein–protein complex mutations using free energy perturbation calculations

Life Science Publication

Study of key residues in MERS-CoV and SARS-CoV-2 main proteases for resistance against clinically applied inhibitors nirmatrelvir and ensitrelvir

Life Science Publication

Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies

Life Science Publication

Predictive modeling of concentration-dependent viscosity behavior of monoclonal antibody solutions using artificial neural networks

Life Science Publication

Rational design of a highly immunogenic prefusion-stabilized F glycoprotein antigen for a respiratory syncytial virus vaccine

Life Science Publication

A novel method for in silico assessment of Methionine oxidation risk in monoclonal antibodies: Improvement over the 2-shell model

Life Science Publication

Computational Design and Biological Evaluation of Analogs of Lupin Peptide P5 Endowed with Dual PCSK9/HMG-CoAR Inhibiting Activity

Life Science Publication

A Descriptor Set for Quantitative Structure-Property Relationship Prediction in Biologics

Life Science Publication

Accurate Prediction of Protein Thermodynamic Stability Changes upon Residue Mutation using Free Energy Perturbation

Training & Resources

Online certification courses

Level up your skill set with hands-on, online molecular modeling courses. These self-paced courses cover a range of scientific topics and include access to Schrödinger software and support.

Tutorials

Learn how to deploy the technology and best practices of Schrödinger software for your project success. Find training resources, tutorials, quick start guides, videos, and more.