Glide
Industry-leading ligand-receptor docking solution
Interactively design and dock in 3D using goal-directed ligand design workflows in Ligand Designer and LiveDesign
Amplify your ligand discovery with an accurate, versatile docking program
Glide is the leading industrial solution for reliable ligand-receptor docking. It augments and accelerates structure-based drug design across a range of applications, including virtual screening, binding mode prediction and interactive 3D molecular design.
Advantages of Glide for ligand-receptor docking
Easy-to-use graphical interface
Easily create and validate docking models with a simple, guided graphical user interface
High docking accuracy across diverse receptor types
Achieve high enrichment across a diverse range of receptor types, including small molecules, peptides, and macrocycles
Customizable constraints
Benefit from a broad range of constraints to easily bias docking calculations to meet experimentally-observed requirements and desired chemical space
Optionally leverages explicit water energetics
Achieve accurate pose predictions and eliminate false positive virtual hits with Glide WS
Includes multiple scoring workflows to enhance your virtual screens
Glide SP is a widely used and precise docking workflow designed for high-throughput virtual screens. Glide SP employs hierarchical filter technology that is ideal for large-scale screening to yield fast and accurate hits.
Glide WS is an advanced docking tool that leverages explicit water dynamics from WaterMap. Built on the foundation of Glide SP and WScore, Glide WS provides significantly improved sampling and scoring of small molecules in the binding pocket.
Glide is a key element of Schrödinger’s modern virtual screening workflow
Powerful use cases across drug discovery
Interactive 3D design
Pose prediction
Accurately predict ligand poses to understand interaction with receptor and provide initial pose for rescoring with AB FEP+
Virtual screening
Perform virtual screens with automated workflows that are customizable to fit project needs and accelerate screening of ultra-large libraries (>1B compounds) using Glide enhanced by Active Learning
Covalent docking and scoring
Dock a set of ligands that bind covalently to the receptor, using predefined or custom reaction chemistry – CovDock
Rescoring with Glide WS
Incorporate detailed water analysis from WaterMap calculations to evaluate protein-ligand binding interactions and reduce false positives from Glide SP screenings
Save compute time and effort using prepared commercial libraries for Glide
Schrödinger has partnered with leading providers to help you access commercial databases of fragments, lead-like, near drug-like, and drug-like compounds ranging from millions to billions of compounds encompassing a vast chemical space.
Case studies & webinars
Discover how Schrödinger technology is being used to solve real-world research challenges.
Docking and scoring
20 years of Glide: A legacy of docking innovation and the next frontier with Glide WS
Water matters: Enhancing early drug discovery with insights from water energetics
Expect Success: Modern Virtual Screening Technologies that Actually Deliver High-Quality, Developable Hits
Dramatically improving hit rates with a modern virtual screening workflow
Documentation & Tutorials
Get answers to common questions and learn best practices for using Schrödinger’s software.
Related Products
Learn more about the related computational technologies available to progress your research projects.
Publications
Browse the list of peer-reviewed publications using Schrödinger technology in related application areas.
Training & Resources
Online certification courses
Level up your skill set with hands-on, online molecular modeling courses. These self-paced courses cover a range of scientific topics and include access to Schrödinger software and support.
Tutorials
Learn how to deploy the technology and best practices of Schrödinger software for your project success. Find training resources, tutorials, quick start guides, videos, and more.
Other Resources