- Tutorial
Antibody Visualization and Modeling in BioLuminate
Visualize, build, and evaluate antibody models, analyze an antibody for various characteristics, dock an antigen to an antibody.
- Tutorial
Identifying impactful mutations using FEP+ residue scanning
Perform an FEP+ residue scan for identifying the impact of mutations on the stability and affinity of a protein-protein system.
Webinar
Life Science
- Oct 20, 2022
Accelerating Antibody Drug Discovery Through Computational Modeling
In this webinar, we provide an overview of computational modeling strategies for antibody design.
Webinar
Life Science
Webinar
Life Science
Webinar
Life Science
- May 27, 2020
Antibody modeling with the Schrödinger Platform
This webinar presents the tools available in BioLuminate to model antibody structures, covering homology modeling, humanization, antigen-antibody docking, liability prediction, and in silico mutations.
Webinar
Life Science
- May 4, 2019
Homology modeling with the Schrödinger Biologics Suite
In this webinar, we present a short introduction to homology modeling followed by a a demonstration of how to use Schrödinger tools to build and analyze homology models.
Webinar
Life Science
- May 14, 2025
MAY 14, 2025 | Schrödinger デジタル創薬セミナー17 | Schrödinger’s approach to physics-based antibody analysis and design
Schrödinger’s approach to physics-based antibody analysis and design
- Tutorial
Introduction to T-Cell Receptor Modeling with BioLuminate
Structure preparation, visualization and analysis of key interactions in the TCR-peptide-MHC complex.
- Publication
- Aug 23, 2024
Novel druggable space in human KRAS G13D discovered using structural bioinformatics and a P-loop targeting monoclonal antibody
Jungholm O et al., Scientific Reports, 2024, 14(1), 19656- Publication
- Aug 15, 2024
Robust prediction of relative binding energies for protein–protein complex mutations using free energy perturbation calculations
Sampson, et al. Journal of Molecular Biology, 2024, 436, 16, 168640- Publication
- Jun 24, 2024
Study of key residues in MERS-CoV and SARS-CoV-2 main proteases for resistance against clinically applied inhibitors nirmatrelvir and ensitrelvir
Krismer L et al., Npj Viruses, 2024, 2(1), 23Case Studies
Case Study
Life Science
Materials Science
Case Study
Life Science
Case Study
Life Science
Documentation
- Documentation
LiveDesign Documentation
Information and instruction on how to use Schrödinger’s LiveDesign platform including user manuals, tutorials, cheatsheets, and workflows.
- Documentation
Learning Path: Computational Structure Prediction
A structured overview of tools and workflows for predicting biomacromolecular structures in whole or in part.
Events
Event
Life Science
- Sep 15th-17th, 2025
US User Group Meeting 2025
Schrödinger is excited to host the US User Group Meeting (UGM) at the Newport Harbor Island Resort in Newport, Rhode Island, from September 15-17, 2025.
Event
Materials Science
- Jul 23, 2025
Schrödinger User Group Meeting – Materials Science Japan 2025 Part 3
Formulation and cosmeticsをテーマに､最新機能､応用事例､今後の展望などをご紹介します。User Group Meeting (UGM)
Event
Life Science
- Jul 2nd-4th, 2025
RICT 2025
Schrödinger is excited to be participating in the RICT – 59th International Conference on Medicinal Chemistry conference taking place on July 2nd – 4th in Orléans, France.
Product Videos
Video
Life Science
Getting Going with Maestro BioLuminate
A free video series introducing the basics of using Maestro Bioluminate.
Video
Life Science
Video
Life Science
A Sneak Peek into Renumbering Residues and the Project Table in BioLuminate
The sixth video in the Getting Going with Maestro BioLuminate Video Series: renaming chains and residues, the Project Table.
Publications
- Publication
- May 9, 2025
Efficient long-range machine learning force fields for liquid and materials properties
Weber JL, et al. arXiv, 2025, Preprint- Publication
- Apr 18, 2025
Enabling in-silico Hit Discovery Workflows Targeting RNA with Small Molecules
Chopra, et al. Theoretical and Computational Chemistry, 2025, 1, Preprint- Publication
- Apr 17, 2025
Active Learning FEP: Impact on Performance of AL Protocol and Chemical Diversity
Lonsdale, et al. Journal of Chemical Theory and Computation, 2025Quick Reference Sheets
- Quick Reference Sheet
Structure Reliability Report
A one-page guide to understanding the outputs of the Structure Reliability Report.
Tutorials
- Tutorial
Structure-Based Virtual Screening using Glide
Prepare receptor grids for docking, dock molecules and examine the docked poses.
- Tutorial
Ligand Binding Pose Prediction for FEP+ using Core-Constrained Docking
Generate starting poses for FEP simulations for a series of BACE1 inhibitors using core constrained docking.
- Tutorial
Antibody Visualization and Modeling in BioLuminate
Visualize, build, and evaluate antibody models, analyze an antibody for various characteristics, dock an antigen to an antibody.
Webinars
Webinar
Life Science
- May 21, 2025
Advancing drug discovery programs with machine learning-enhanced de novo design
In this webinar, we will demonstrate how large-scale de novo design workflows in Schrödinger’s AutoDesigner, combined with rigorous free energy-based scoring methods, have been applied to several recent programs to overcome critical design challenges.
Webinar
Life Science
Materials Science
- May 14, 2025
Computational insights into polymer excipient selection for amorphous solid dispersions
In this webinar, we will highlight how molecular models can aid our ability to screen through standard polymer excipients for target lists to push into lab testing.
Webinar
Life Science
- May 14, 2025
MAY 14, 2025 | Schrödinger デジタル創薬セミナー17 | Schrödinger’s approach to physics-based antibody analysis and design
Schrödinger’s approach to physics-based antibody analysis and design
White Papers
White Paper
Life Science
- Oct 29, 2024
20 Years of Glide: A Legacy of Docking Innovation and the Next Frontier with Glide WS
Glide has long set the gold standard for commercial molecular docking software due to its robust performance in both binding mode prediction and empirical scoring tasks, ease of use, and tight integration with Schrödinger’s Maestro interface and molecular discovery workflows.
White Paper
Life Science
White Paper
Life Science
Latest insights from Extrapolations blog
With FEP+, “The Experiment is the Limit.”
Over the past century, small molecule drugs have represented the dominant modality in drug research, enabling medical breakthroughs that have saved countless lives.
Tackling Drug Solubility: AbbVie and Schrödinger Collaborate to Advance Accurate Prediction Methods
The complexity and size of drug candidates has grown in recent years as scientists pursue novel targets once considered undruggable.
Blog
Can AlphaFold Models be Used for Structure-Based Drug Design? A Perspective Two Years In
We recently sat down with Edward Miller, Senior Director of Protein Structure Modeling at Schrödinger, to discuss his experience using AlphaFold models for SBDD.
Training & Resources
Online certification courses
Level up your skill set with hands-on, online molecular modeling courses. These self-paced courses cover a range of scientific topics and include access to Schrödinger software and support.
Free learning resources
Learn how to deploy the technology and best practices of Schrödinger software for your project success. Find training resources, tutorials, quick start guides, videos, and more.
Other Resources